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NetBuilder examples

Graphical representation and simulation of genetic regulatory networks

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NetBuilder screenshots

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Design screen: View of the Genome

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Simulation screen: View of the Nucleus

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Feedback in NetBuilder
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The community effect: positive feedback

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Auto-inhibition: negative feedback

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Endo16 simulation by Christophe Battail

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The network

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Results

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Endo-mesoderm specification simulation

The GRN underlying endo-mesodermal specification in S. purpuratus

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Setting the scene

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View of the Genome

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View of the Nucleus:
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before the start of the simulation

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during the early development stages

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20-24 hours after fertilisation:
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effect of Delta-Notch signal

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GataE and downstream targets switched on

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into gastrulation

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final stages: Wnt8 repressor active

 

 

 

last modified Wednesday, 27 March 2002